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One Note at a Time is a documentary that chronicles the return of local musicians to New Orleans in the aftermath of Hurricane Katrina and the ensuing floods. Told through "the prism of the New Orleans' Musicians' Clinic," the film examines both the resurgence of the local music scene and the ongoing need for health and wellness services for the city's culture-bearers.

Musicians appearing in the film as interviewees or performers include Dr. John, Kermit Ruffins, Irma Thomas, Ellis Marsalis, Ben Jaffe and "Uncle" Lionel Batiste, who died in 2012.?