LongTimeFan

IMO the Saints will run the ball and run often, I don't think the Colts can do a very good job stopping Bush and Deuce, if the run works well as I think it will the Colts defense will be on the field a lot and we'll beat them in the 4th QTR..
As for the Colts offense I think they are still very dangerous and our defense will have to play a very good game, P. Manning is very comfortable in the pocket, if I'm Sean I'd take chances and go after him early in the game , a sack would be a nice start for the Saints defense but just getting in his face will throw his game off some, we can't stop him every play but we need to do just enough to keep him guessing and without a decent running game the Saints will take even more chances, look for Will Smith to have a big game.
Bottom line: This will be the hardest game for the Saints this season, a win would carry them far down the road in beating the Champs from last season..
Not sure who's #21 for the Colts, he's a safety that also plays the pass extreamly well, Brees will have to make sure where he's at at all times.

Rest In Peace JoeSam, thanks for everything my friend.