Yes you could say so. A lot of the blocking has to do with trying to set an edge by reachblocking the EMLOS (end man on line of scrimmage). This is usually done by the tackle alone or together with a TE or FB. When the edge is set the HB can run on the outside. On the backside you cut everything down and create cutback lanes. Thats in theory atleast.
In reality a lot of times you get a full flow along the line and holes open up in the middle of it instead of on the outside and then the RB needs to hit that hole and usually cut to the direction of the pressure meaning if you run outside zone to the left the HB hits the hole and cuts back to the right. A lot of time this cause the flowing defender to over pursuit the play and miss the tackles.

Denver Broncos with Terrell Davis were great at the outside zone. Here is som video of it:

Outside Zone Cut-Ups terrell davis alex gibbs - YouTube

A screen pass isn't really comparable, for a screen you usually invite the defensive linemen upfield without blocking them and then release the O-line to the second level to block which in theory gives you a lot more blockers than defenders. But a screen isn't based on flow in the same way a zone play are. Both require good vision and decisiveness from the RB thou.